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Promising therapies for treatment of male infertility and age- related fertility challenges

Deadline for manuscript submissions: 20 December 2026

Special Issue Editor

Guest Editor

Dr. Mónica Beatriz Frungieri, PhDE-Mail Website

Principal Researcher at the National Scientific and Technical Research Council of Argentina (CONICET); Director of the Laboratory of Testicular Neuroimmunoendocrinology, Institute of Biology and Experimental Medicine (IBYME), Buenos Aires, Argentina

Interests: Andrology Basic and Clinical Research; Idiopathic Male Infertility; Testicular Aging; Therapeutic and Anti-aging Interventions in Andrology

Special Issue Information

Male factors are responsible for up to 50% of cases of infertility and, in 25% of these cases, the etiology of male infertility is unknown. Impaired spermatogenesis and infertility of unknown origin are often accompanied by signs of testicular inflammation, oxidative stress and fibrosis.

Aging is linked to changes in the hypothalamic-pituitary-testicular axis. The reproductive system undergoes fluctuations in the production of sexual hormones, loss of libido and a gradual decline in fertility. Therefore, aging leads to a progressive decline of gonadal function affecting not only fertility but also the quality of life and life span. The oxidation-inflammation theory underlines the interdependence between oxidative stress and the occurrence of inflammatory process in the age-related impairment of the male reproductive function.

New and promising therapies are currently emerging for the treatment of idiopathic male infertility as well as anti-aging drugs to protect elder men’s reproductive activity and general health status.

This call-for-papers is aimed at providing a platform for the dissemination of critical and novel ideas related to the exploration of novel therapeutic drugs to target male infertility, to delay reproductive senescence in men and/or to alleviate the negative health consequences of aging.

We welcome manuscripts, review articles and short communications, in English and Spanish, focused on understanding the mechanisms that regulate male fertility and longevity, including identification of novel compounds to alleviate the harmful consequences of sexual dysfunction and aging on steroidogenesis spermatogenesis and semen quality, the molecular and cellular mechanisms associated, and the relationship to overall organismal health span.

Keywords

Aging; (In)Fertility; Semen; Sperm; Testis

Manuscript Submission Information

Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Revista Internacional de Andrología is an international peer-reviewed open access journal published by MRE Press. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $1500. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.