Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Therapeutic use of platelet-rich plasma for the treatment of male infertility
Uso terapéutico del plasma rico en plaquetas para el tratamiento de la esterilidad masculina
1IVI Barcelona, 08017 Barcelona, Spain
2Universidad Europea (Campus Alcobendas), 28108 Alcobendas, Spain
DOI: 10.22514/j.androl.2024.018 Vol.22,Issue 3,September 2024 pp.16-23
Submitted: 26 April 2024 Accepted: 02 July 2024
Published: 30 September 2024
*Corresponding Author(s): Paula Alonso-Frías E-mail: paula.alonso@ivirma.com
Platelet-Rich Plasma (PRP) is a regenerative therapy that has gained interest in recent years, being the subject of various studies and applications. In the field of human reproduction specifically, there are growth factors (GFs) present in PRP that have shown an impact on sperm quality and function. The main objective of this article is to conduct a literature review on the use of PRP for the treatment of male infertility. To achieve this, a bibliographic search of articles and reviews in scientific journals about the possible use of PRP for the treatment of male factor published between 2018 and 2023 has been carried out. Nine publications were identified, proposing the application of PRP in the following areas: sperm cryopreservation, oxidative stress, culture of spermatogonial stem cells, and secretory azoospermia. According to the literature, supplementing the cryopreservation medium with PRP improves sperm parameters, and samples incubated with PRP show an increase in their antioxidant capacity. Finally, PRP can increase the proliferation and vitality of spermatogonial stem cells and sperm recovery in cases of non-obstructive azoospermia. PRP shows therapeutic potential in various aspects of the male factor. Further research with a larger sample size is needed to define both its protocols and its clinical efficacy.
Resumen
La terapia regenerativa conocida como Plasma Rico en Plaquetas (PRP) ha captado una creciente atención en los últimos años, siendo objeto de diversos estudios y aplicaciones. En el campo de la reproducción humana en concreto, hay factores de crecimiento (FCs) presentes en el PRP que han mostrado impacto en la calidad y función espermática. El objetivo principal de este artículo es realizar una revisión bibliográfica sobre el uso del PRP para el tratamiento de la esterilidad masculina, para ello se ha llevado a cabo una búsqueda bibliográfica de artículos y revisiones en revistas científicas acerca del posible uso del PRP para el tratamiento del factor masculino publicados entre los años 2018 y 2023. Se identificaron 9 publicaciones, que proponían la aplicación del PRP en las siguientes áreas: la criopreservación espermática, el estrés oxidativo, el cultivo de células madre espermatogoniales y la azoospermia secretora. Según la bibliografía, suplementando el medio de criopreservación con PRP conseguimos mejorar los parámetros espermáticos y las muestras incubadas con PRP presentan un aumento en su capacidad antioxidante. Por último, el PRP es capaz de incrementar la proliferación y vitalidad de las células madre espermatogoniales y la recuperación espermática en casos de azoospermia no obstructiva. El PRP muestra un potencial terapéutico en varios aspectos del factor masculino. Se requieren más estudios con un mayor tamaño de muestra para establecer tanto los procedimientos de obtención y uso como la efectividad de esta terapia.
Platelet-rich plasma; Male infertility; Sperm cryopreservation; Oxidative stress; Spermatogonial cell culture
Palabras Clave
Plasma rico en plaquetas; Infertilidad masculina; Criopreservación de esperma; Estrés oxidativo; Cultivo de células madre espermatogoniales
Paula Alonso-Frías,Marga Esbert. Therapeutic use of platelet-rich plasma for the treatment of male infertilityUso terapéutico del plasma rico en plaquetas para el tratamiento de la esterilidad masculina. Revista Internacional de Andrología. 2024. 22(3);16-23.
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