The impact of vitamin B12 treatment on ejaculatory functions in men: symptomatic relief and improved outcomes

El impacto del tratamiento con vitamina B12 en las funciones eyaculatorias del hombre: alivio sintomático y mejora de los resultados

Background: To investigate whether intramuscular vitamin B12 treatment has an effect on ejaculaory functions in male patients with vitamin B12 deficiency. Methods: Male patients diagnosed with vitamin B12 deficiency in the internal medicine outpatient clinic of our hospital between October 2024 and March 2025 and started to receive intramuscular vitamin B12 treatment were included in study. The scores obtained from the self-estimated intravaginal ejaculation latency time (IELT), premature ejaculation diagnostic tool (PEDT), and premature ejaculation profile (PEP) questionnaires, reflecting the ejaculatory status of these patients before treatment, were recorded. After 3 months of treatment, these scores were re-recorded via phone calls, and scores recorded before and after treatment were compared. Results: The study included 54 patients. The mean age of the patients was 43.46 ± 13.3 years, the mean pretreatment IELT was 2.4 ± 1.4 min, and the mean pre-treatment PEDT score was 11.5 ± 4.6. In both the whole patient group and the premature ejaculation (PE) group, a statistically significant difference was observed in the items of perceived control over ejaculation, satisfaction with sexual intercourse, and interpersonal difficulty related to ejaculation from the PEP questionnaire forms completed after treatment, with no significant change found in the item of personal distress related to ejaculation. In terms of IELT and PEDT, no differences were observed in the whole patient group after treatment, whereas a statistically significant improvement was observed in the PE group. Conclusions: Intramuscular vitamin B12 may delay ejaculation times and improve sexual satisfaction levels in male patients based on the responses given by the patients to the questions in the survey forms. Clinical Trial Registration: The study was registered with ClinicalTrials.gov as: NCT07036497.

Resumen

Antecedentes: Investigar si el tratamiento intramuscular con B12 tiene un efecto sobre la eyaculación en pacientes varones con deficiencia de B12. Métodos: Se incluyeron en el estudio pacientes varones a los que se diagnosticó deficiencia de vitamina B12 en la consulta externa de medicina interna entre octubre de 2024 y marzo de 2025 y que iniciaron tratamiento intramuscular con B12. Se registraron las puntuaciones obtenidas en los cuestionarios de tiempo de latencia de la eyaculación intravaginal autoestimado (IELT), herramienta de diagnóstico de la eyaculación precoz (PEDT) y perfil de eyaculación precoz (PEP), que reflejaban el estado eyaculatorio de estos pacientes antes del tratamiento. Tras 3 meses de tratamiento, se volvieron a registrar estas puntuaciones mediante llamada telefónica. Se compararon las puntuaciones registradas antes y después del tratamiento. Resultados: En el estudio participaron 54 pacientes. La media de edad de los pacientes era de 43.46 ± 13.3 años, la media de IELT antes del tratamiento era de 2.4 ± 1.4 min y la media de puntuación PEDT antes del tratamiento era de 11.5 ± 4.6. En el grupo de pacientes completo y en el grupo de pacientes antes del tratamiento se registraron las puntuaciones antes y después del tratamiento. Tanto en el grupo de pacientes completos como en el grupo de eyaculación precoz (EP), se observó una diferencia estadísticamente significativa en los ítems de control percibido sobre la eyaculación, satisfacción con las relaciones sexuales y dificultad interpersonal relacionada con la eyaculación del formulario del cuestionario PEP después del tratamiento, no se encontraron cambios significativos en el ítem de angustia personal relacionada con la eyaculación. En términos de IELT y PEDT, no se observaron diferencias en todo el grupo de pacientes después del tratamiento, mientras que se observó una mejora estadísticamente significativa en el grupo de PE. Conclusiones: La vitamina B12 intramuscular puede mejorar los tiempos de eyaculación y los niveles de satisfacción en los cuestionarios de los pacientes varones. Registro del Ensayo Clínico: El estudio se registró en ClinicalTrials.gov como: NCT07036497.

Premature ejaculation; Intravaginal ejaculatory latancy time; Premature ejaculation diagnostic tool; Vitamin B12; Premature ejaculation profile

Palabras Clave

Eyaculación precoz; Tiempo de latencia eyaculatoria intravaginal; Herramienta de diagnóstico de la eyaculación precoz; Vitamina B12; Perfil de eyaculación precoz

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